LAB RESOURCES
Cell
Lines
Mouse
Alveolar Macrophage - MH-S
Raw Macrophage - RAW 267.4
Tranformed Epithelial - MLE 12
Human
Human Alveolar Basal Epithelial - A549
Human ABE Tissue Factor KO - A549 TF KO
Small Airway Epithelial - SAEC
Micovascular Endothelial - HULEC
Pulmonary Microvascular Endothelial - HPMVEC
Primary Umbilical Vein Endothelial - HUVEC
Primary Lung Microvascular Endothelial - HLMVEC
Primary Brain Microvascular Endothelial - HBMVEC
Primary Lymphatic Endothelial - HLEC
Primary Cardiac Endothelial - HCMEC
Mouse
Lines
BioBank
Specimens
HMEF: ICU collection of exhaled breath from patients with pulmonary edema (300 subjects)
VALID: ICU ARDS patients (~3,000 subjects, plasma, serum, urine, DNA)
Cell
Lines
Mouse
Alveolar Macrophage - MH-S
Raw Macrophage - RAW 267.4
Tranformed Epithelial - MLE 12
Human
Human Alveolar Basal Epithelial - A549
Human ABE Tissue Factor KO - A549 TF KO
Small Airway Epithelial - SAEC
Micovascular Endothelial - HULEC
Pulmonary Microvascular Endothelial - HPMVEC
Primary Umbilical Vein Endothelial - HUVEC
Primary Lung Microvascular Endothelial - HLMVEC
Primary Brain Microvascular Endothelial - HBMVEC
Primary Lymphatic Endothelial - HLEC
Primary Cardiac Endothelial - HCMEC
Mouse
Lines
BioBank
Specimens
HMEF: ICU collection of exhaled breath from patients with pulmonary edema (300 subjects)
VALID: ICU ARDS patients (~3,000 subjects, plasma, serum, urine, DNA)
LAB EQUIPMENT
Cell
Lines
Mouse
Alveolar Macrophage - MH-S
Raw Macrophage - RAW 267.4
Tranformed Epithelial - MLE 12
Human
Human Alveolar Basal Epithelial - A549
Human ABE Tissue Factor KO - A549 TF KO
Small Airway Epithelial - SAEC
Micovascular Endothelial - HULEC
Pulmonary Microvascular Endothelial - HPMVEC
Primary Umbilical Vein Endothelial - HUVEC
Primary Lung Microvascular Endothelial - HLMVEC
Primary Brain Microvascular Endothelial - HBMVEC
Primary Lymphatic Endothelial - HLEC
Primary Cardiac Endothelial - HCMEC
TransGenic Mouse
Lines
CD-163 Knock-Out
LysM-CreTLR4 fl/fl (macrophage specific KO)
SpC-Cre TLR4 fl/fl (epithelial specific KO)
Global TLR4 Knock-Out
RAGE Knock-Out
NLRP3 Knock-Out
TRIF Knock-Out
MyD-88 Knock-Out
Townes Sickle Cell
SPC.Cre Tissue Factor fl/fl (lung epithelial specific KO)
SPC.Cre Teto-Tissue Factor RTTA (Tissue Factor Overexpressers)
Humanized Haptoglobin Mice
NFKb Reporter Mice
BioBank
Specimens
HMEF: ICU collection of exhaled breath from patients with pulmonary edema (300 subjects and growing)
VALID: Observational study of ICU ARDS patients (~3,000 subjects, plasma, serum, urine, DNA)
TRANSPLANT: Exhaled breath, tissue, and plasma from hundreds of lung donors and recipients at multiple sites
Grant
Funding
R35 Applying Innovative Lung Mapping Strategies to Understand Alveolar Capillary Barrier Permeability in ARDS
R01 Targeting Cell-Free Hemoglobin in Sepsis to Reduce Lung Microvascular Permeability: Mechanistic and Translational Studies
VA Merit Potential Protective Mechanisms of Tissue Factor in Acute Lung Injury
R35 Applying Innovative Lung Mapping Strategies to Understand Alveolar Capillary Barrier Permeability in ARDS
K24 Midcareer Investigator Award in Patient-Oriented Research in Acute Lung Injury
R01 The Gold Study: Goal of Open Lung Ventilation in Donors
DoD Shedding of Alveolar Heparan Sulfate Mediates Epithelial Dysfunction in Experimental and Human ARDS
K08 Mechanisms of Airspace Inflammation Caused by Cell-Free Hemoglobin During ARS=
