LAB RESOURCES

Cell

Lines

Mouse

Alveolar Macrophage - MH-S

Raw Macrophage - RAW 267.4

Tranformed Epithelial - MLE 12

Human

Human Alveolar Basal Epithelial - A549

Human ABE Tissue Factor KO - A549 TF KO

Small Airway Epithelial - SAEC

Micovascular Endothelial - HULEC

Pulmonary Microvascular Endothelial - HPMVEC

Primary Umbilical Vein Endothelial - HUVEC

Primary Lung Microvascular Endothelial - HLMVEC

Primary Brain Microvascular Endothelial - HBMVEC

Primary Lymphatic Endothelial - HLEC

Primary Cardiac Endothelial - HCMEC

Mouse

Lines

BioBank

Specimens

HMEF: ICU collection of exhaled breath from patients with pulmonary edema (300 subjects)

VALID: ICU ARDS patients (~3,000 subjects, plasma, serum, urine, DNA)

Cell

Lines

Mouse

Alveolar Macrophage - MH-S

Raw Macrophage - RAW 267.4

Tranformed Epithelial - MLE 12

Human

Human Alveolar Basal Epithelial - A549

Human ABE Tissue Factor KO - A549 TF KO

Small Airway Epithelial - SAEC

Micovascular Endothelial - HULEC

Pulmonary Microvascular Endothelial - HPMVEC

Primary Umbilical Vein Endothelial - HUVEC

Primary Lung Microvascular Endothelial - HLMVEC

Primary Brain Microvascular Endothelial - HBMVEC

Primary Lymphatic Endothelial - HLEC

Primary Cardiac Endothelial - HCMEC

Mouse

Lines

BioBank

Specimens

HMEF: ICU collection of exhaled breath from patients with pulmonary edema (300 subjects)

VALID: ICU ARDS patients (~3,000 subjects, plasma, serum, urine, DNA)

LAB EQUIPMENT

 

Cell

Lines

Mouse

Alveolar Macrophage - MH-S

Raw Macrophage - RAW 267.4

Tranformed Epithelial - MLE 12

Human

Human Alveolar Basal Epithelial - A549

Human ABE Tissue Factor KO - A549 TF KO

Small Airway Epithelial - SAEC

Micovascular Endothelial - HULEC

Pulmonary Microvascular Endothelial - HPMVEC

Primary Umbilical Vein Endothelial - HUVEC

Primary Lung Microvascular Endothelial - HLMVEC

Primary Brain Microvascular Endothelial - HBMVEC

Primary Lymphatic Endothelial - HLEC

Primary Cardiac Endothelial - HCMEC

TransGenic Mouse

Lines

CD-163 Knock-Out

LysM-CreTLR4 fl/fl (macrophage specific KO)

SpC-Cre TLR4 fl/fl (epithelial specific KO)

Global TLR4 Knock-Out

RAGE Knock-Out

NLRP3 Knock-Out

TRIF Knock-Out

MyD-88 Knock-Out

Townes Sickle Cell

SPC.Cre Tissue Factor fl/fl (lung epithelial specific KO)

SPC.Cre Teto-Tissue Factor RTTA (Tissue Factor Overexpressers)

Humanized Haptoglobin Mice

NFKb Reporter Mice

BioBank

Specimens

HMEF: ICU collection of exhaled breath from patients with pulmonary edema (300 subjects and growing)

VALID: Observational study of ICU ARDS patients (~3,000 subjects, plasma, serum, urine, DNA)

TRANSPLANT: Exhaled breath, tissue, and plasma from hundreds of lung donors and recipients at multiple sites

Grant

Funding

R35 Applying Innovative Lung Mapping Strategies to Understand Alveolar Capillary Barrier Permeability in ARDS

R01 Targeting Cell-Free Hemoglobin in Sepsis to Reduce Lung Microvascular Permeability: Mechanistic and Translational Studies

VA Merit Potential Protective Mechanisms of Tissue Factor in Acute Lung Injury

R35 Applying Innovative Lung Mapping Strategies to Understand Alveolar Capillary Barrier Permeability in ARDS

K24 Midcareer Investigator Award in Patient-Oriented Research in Acute Lung Injury

R01 The Gold Study: Goal of Open Lung Ventilation in Donors

DoD Shedding of Alveolar Heparan Sulfate Mediates Epithelial Dysfunction in Experimental and Human ARDS

K08 Mechanisms of Airspace Inflammation Caused by Cell-Free Hemoglobin During ARS=

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